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host cell proteins is a type of protein mixture that is produced by genetic engineering strain or cell line with nothing to do with the purpose of genetic engineering, some of these proteins is necessary in the production process, engineering strains or cell lines survival, reproduction, and other normal physiological activities, with the objective product purification and cannot be removed, meanwhile, the composition and abundance of the host cell proteins at all stages of production and the final product are quite different, it is up to many different factors.