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Although the primary mechanistic rationale invoked for agonistic CD40 mAb is to activate host APC, especially DC, to induce clinically meaningful antitumor T-cell responses in patients, other immune m...
Preclinical pancreatic, melanoma, thyroid, prostate, and colon cancer24 models revealed that directed metastasis of cancer cells is mediated by CXCR4 activation and migration of cancer cells towards C...
Expression of CTLA-4 is primarily restricted to T cells, although the expression on B cells and other cell types has been described. Compared with CD28 which is expressed on the surface of resting and...
CD200 is expressed on thymocytes, activated T cells, B cells, dendritic cells (DCs), hair follicular cells, vascular endothelial cells, in the central nervous system and in the retina.
CD200 and CD200R molecules are involved in the downregulation of myeloid and lymphoid cells. They provide immunomodulatory effects, are able to induce immune tolerance, regulate all differentiation, a...
The fosmid system has been widely used in the construction of large-insert genomic libraries. Fosmid clones are similar in insert size comparing with cosmid clones and smaller than that in BAC and yea...
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B-amino acids are key structural elements of peptides, peptidomimetics and many other physiologically active compounds. Notably, b-amino acids are precursors for b-lactams, the most important class of...